NCMHCE · Anxiety

Panic disorder & agoraphobia

High-yield18 CaseSavvy case questions test this

Panic cases test two linked skills: telling panic disorder from a panic attack that is just a feature of something else, and recognizing agoraphobia as its own diagnosis that can stand alone or co-occur.

Panic attack. An abrupt surge of intense fear or discomfort that peaks within minutes, with four or more of thirteen physical and cognitive symptoms (pounding heart, sweating, trembling, shortness of breath, choking sensation, chest pain, nausea, dizziness, chills or heat sensations, numbness or tingling, derealization or depersonalization, fear of losing control or "going crazy," fear of dying). Attacks can occur in any disorder; when they do not define panic disorder, they are recorded as a "with panic attacks" specifier on the other diagnosis.

Panic disorder at exam depth. Recurrent unexpected panic attacks, with at least one followed by one month or more of persistent worry about more attacks or their consequences (heart attack, losing control) and/or a significant maladaptive change in behavior to avoid them (avoiding exercise or unfamiliar places). Not due to a substance or medical condition, and not better explained by another disorder (for example, attacks only in feared social situations or only to a specific phobic object).

Agoraphobia at exam depth. Marked fear or anxiety about two or more of five situations: public transportation, open spaces, enclosed spaces, standing in line or being in a crowd, and being outside the home alone. The client fears these because escape might be difficult or help unavailable if panic-like or embarrassing symptoms occur; the situations are avoided, require a companion, or are endured with intense fear. The fear is out of proportion, lasts six months or more, and causes impairment. Agoraphobia is diagnosed regardless of whether panic disorder is present; when both are met, both are diagnosed.

Hinge differentials.

  • Specific phobia, situational type: fear limited to one situation type.
  • Social anxiety disorder: fear of negative evaluation, not of being trapped without help.
  • GAD: chronic diffuse worry rather than discrete attacks.
  • PTSD: attacks and avoidance triggered by trauma reminders.
  • Medical conditions: cardiac arrhythmia, hyperthyroidism, asthma, pheochromocytoma, hypoglycemia.
  • Substances: stimulants, caffeine, cannabis, and withdrawal from alcohol or sedatives.

On the NCMHCE. Many clients first seek emergency care for an attack; the counselor still recommends a medical evaluation (cardiac, thyroid) when it has not been done, and screens caffeine, stimulant and alcohol use. Track attack frequency separately from general anxiety scores, since one can improve while the other does not. First-line treatment is CBT for panic: psychoeducation about the fight-or-flight response, cognitive restructuring of catastrophic misinterpretations, interoceptive exposure to feared bodily sensations, and in vivo exposure for agoraphobic avoidance. Reduce safety behaviors gradually. Refer for medication evaluation when needed (SSRIs are a common class; benzodiazepines carry dependence concerns). Screen for depression and suicide risk.

Clinical Pearl: Panic disorder needs unexpected attacks plus a month of worry or behavior change; agoraphobia needs two of five situations for six months and is diagnosed on its own. Interoceptive exposure is the signature intervention.

Cheat sheet

Criteria at a glance

ElementPanic attackPanic disorderAgoraphobia
CoreAbrupt surge, peaks within minutesRecurrent unexpected attacksFear of 2+ of 5 situation types
Count4 of 13 symptomsAt least one attack followed by worry/behavior change2 of 5 situations
DurationMinutes1+ month of worry or behavior change6+ months
Diagnosis statusSpecifier on other disordersStandaloneStandalone; can co-occur with panic disorder

Agoraphobia's five situations

  • Public transportation
  • Open spaces (parking lots, bridges, markets)
  • Enclosed spaces (stores, theaters)
  • Lines or crowds
  • Outside the home alone

Differentials

Look-alikeWhat separates it
Specific phobia, situationalOnly one situation type feared
Social anxiety disorderFear of scrutiny, not of being trapped
GADDiffuse chronic worry, no discrete unexpected attacks
PTSDTriggered by trauma reminders
Cardiac/thyroid/respiratory illnessMedical cause on workup
Stimulants, caffeine, withdrawalAttacks track use or cessation

Red flags / first moves

  • Medical evaluation (cardiac, thyroid) if not done
  • Screen caffeine, stimulants, alcohol and sedative use
  • Monitor attack frequency separately from anxiety scores
  • CBT: psychoeducation, cognitive restructuring, interoceptive exposure, in vivo exposure
  • Fade safety behaviors; screen depression and suicide risk

How the NCMHCE-style cases test it

The decisions CaseSavvy’s case questions on this topic ask for most often. Each one has its own strategy.

  • Rule-outs & differentials10 questions
  • Best intervention4 questions
  • Most likely diagnosis2 questions
  • Goals & treatment plan1 question
  • Why it works / what explains it1 question

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Domain 2B: Assessment

Your client is a 21-year-old pre-medical undergraduate who self-referred to the college counseling center after a resident advisor suggested she speak with someone about her stress levels. She reported that her worry has become constant and unmanageable over the past seven months, beginning during the fall semester when she enrolled in organic chemistry and began planning her MCAT preparation timeline. She stated, "I used to be able to just push through the stress, but now I can't turn my brain off — I'm worrying about everything, not just school." She described persistent worry that extends across multiple domains including academic performance, her relationships with friends and family, her financial situation, and her long-term career prospects. She reported difficulty controlling the worry despite recognizing that it is often disproportionate to the actual circumstances. She stated that she frequently catches herself catastrophizing — for example, imagining that a single poor exam score will prevent her from entering medical school, which will lead to financial ruin and disappointing her parents — but she reported being unable to interrupt the thought spiral once it begins. Your client described significant functional impairment. She reported chronic difficulty falling asleep, stating that she lies awake for one to two hours most nights reviewing her study schedule and…

Which observation from the mental status examination most directly helps differentiate the diagnosis from Panic Disorder?

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